James out for two months, while Ramos set to miss derby clash.
Carlo Ancelotti left with four injured players and one suspended against Atletico Madrid.
Real Madrid's summer-signing James Rodriguez and and defender Sergio Ramos was unable to play due to injuries sustained. The duo will be missed against Diego Simeone's men.
Meanwhile, Marcelo has been suspended following a challenge with Vilito. Other option, Fabio Coentrao, is said to be injured according to some reports. Pepe was injured the last time he played against Atletico Madrid.
Madrid must also cope without Luka Modric who was injured for three months back in November.
James Rodriguez successfully completed his surgery and is injured for two months with a broken foot. Sergio Ramos suffered a hamstring injury with just nine minutes into the game against Sevilla.
James Rodriguez scored a stunner against Sevilla but was injured lat in the second half.
However, Real Madrid are set to appeal Marcelo's ban.