Carlo Ancelotti will look to get back to winning ways against Diego Simeone.
Cristiano Ronaldo returns tonight after two-match ban.
Real Madrid will look to extend 10 point-lead over La Liga champions in a tough challenge.
Real will miss Sergio Ramos and James Rodriguez, both of them picked injuries last match, alongside other centre-back Pepe who was taken off the last time they met. Marcelo will also miss tonight's game due to suspension.
Marcelo picked up his fifth yellow of the season against Sevilla after a foul on Vilito. Although, Marcelo said he didn't touch latter, his appeal was rejected.
Nacho and Coentrao will start alongside Varane and Carvajal. Isco, Bale, Kroos and Khedira or Illara may be the midfield package.
Ronaldo, who has returned from suspension after picking up a red against Cordoba, and Benzema, who is at good form, must be the possible attacking duo.
Above lineup will be possible only if the formation is 4-4-2. Bale may turn to right wing if the formation is 4-3-3.
Real had lost three and drew five of their meetings this season, resulting in Supper Copa defeat, Copa del Rey exit and La Liga loss in first meeting.
Atletico Madrid host Real Madrid at Vicente Calderon at Saturday, 16:00 CET.